Special issue symmetry and asymmetry in hostguest chemistry. The host guest chemistry of proflavine with cucurbit6,7,8urils. Michael schmittel, suchismita saha, in advances in inorganic chemistry, 2018. Davis, and is associate editor of the journal of inclusion phenomena and macrocyclic chemistry. The most stable host guest complexes are generally obtained. Her current research interests include development of supramolecular materials and catalysis. In recent years, host guest interaction based supramolecular chemistry, has attracted more and more attention benefiting from their distinctive properties to introduce macrocyclic hosts including cyclodextrins cds, calixnarenes cas, cucurbitnurils cbs, pillarnarenes pas, crown ethers, etc.
Nanoporous supramolecular networks physisorbed on solid surfaces have been extensively used to immobilize a variety of guest molecules. Lehn showed an importance of interaction between molecules, gave tremendous influence on, and initiated huge amount of researches in science. Supramolecular chemistry an overview sciencedirect topics. Supramolecular assemblies for electronic materials. Supramolecular chemistry of nanomaterials department of chemistry imperial college of science, technology and medicine r. Hostguest chemistry in twodimensional supramolecular. Moe key laboratory of macromolecular synthesis and functionalization, department of polymer science and engineering, zhejiang university, 38 zheda road, hangzhou 310027, p. This is my channel about education and that you can use to grow your knowledge related to your study if youre a student who wants to learn chemistry subject to get and. Main concepts of the supramolecular chemistry are molecular selfassembly, molecular recognition and complexation, templatedirected synthesis, mechanically. Presenting over 150 tutorial articles and spanning over 10 comprehensive sections, this new resource covers. Not only the chemists, but biochemists, environmental scientists, engineers, physicists, theoreticians, mathematicians, and a lot of other. A supramolecular diblock copolymer and a supramolecular brush copolymer were prepared by huang et al. Abstract this work presents a synergy between organic electronics and supramolecular chemistry, in which a host guest complex is designed to function as an efficacious electronic material. Supramolecular chemistry, noncovalent bonds, host, guest, recognition, complexation.
Titration of cb8 into a solution of proflavine results in a 95% decrease in fluorescence up to a cb8 to proflavine ratio of 2. Not only the chemists, but biochemists, environmental scientists, engineers, physicists, theoreticians, mathematicians, and a lot of other researchers are also. Supramolecular chemistry simple english wikipedia, the. Nowadays, important concepts that have been demonstrated by supramolecular chemistry include molecular selfassembly, selfsorting and recognition, templated synthesis or host guest chemistry. Combining the concepts of supramolecular chemistry with material science has led to the development of supramolecular polymer chemistry. Host guest chemistry can greatly improve the selectivity of biomoleculeligand binding on account of recognitiondirected interactions. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules. Supra molecular chemistry is one of the most popular areas of experimental chemistry and it seems set to remain that way for the coming future. Supramolecular chemistry lecture 1 1 host guest chemistry host ggc yuest chemistry involves the desigg, yn, synthesis and investigation of simpler organic compounds that imitate working features of naturally occurring compounds. Supramolecular chemistry fundamentals and applications. Chapter 1 introduction to supramolecular chemistry 1. Supramolecular prodrugs based on hostguest interactions.
Concepts supramolecular chemistry wiley online library. Supramolecular chemistry host gust chemistry is a branch of chemistry that examines the noncovalent interactions of molecules and the formation of noncovalent suprastructures. Herein, we describe a rationally designed giant multiarmed hexaphenylbenzene hpb. Encapsulation of guest molecules inside supramolecular host assemblies provides a way to stabilize reactive species in aqueous solution. Supramolecular metallacyclic hydrogels with tunable strength.
Mullick road, kolkata 700032, india s supporting information. The binding of the polyaromatic guest, 3,6diaminoacridine proflavine to cucurbitnuril cbn where n 6, 7 and 8 has been studied by fluorescence spectrophotometry and binding constants determined using a least squares fitting method. Together, pedersen, cram and lehn received the nobel prize for chemistry in 1987. Responsive supramolecular polymers hao yao the key laboratory of space applied physics and chemistry, ministry of education and shanxi key laboratory of macromolecular science and technology, school of science, northwestern polytechnical university, xian, 710072 p. The two components of the compound are held together by noncovalent forces, most commonly by hydrogenbonding. The hostguest chemistry of proflavine with cucurbit6,7,8. Supramolecular hostguest chemistry allows sensitive and selective recognition of a certain substrate by using a rationally designed receptor. It provides you with free online analysis tools for your supramolecular. The development of selective host guest complexes 2, 3 particularly, in which a host molecule. Reinhoudt, in reference module in chemistry, molecular sciences and chemical engineering, 20.
Hostguest chemistry in supramolecular theranostics guocan yu, xiaoyuan chen laboratory of molecular imaging and nanomedicine, national institute of biomedical imaging and bioengineering, national institutes of health, bethesda, maryland 20892, united states. Supramolecular chemistry refers to the study of supramolecular assemblies. Hostguest chemistry in supramolecular theranostics request pdf. Hostguest complex an overview sciencedirect topics. It mainly focuses on the creation and application of sensors. Host guest chemistry encompasses the idea of molecular recognition and interactions through noncovalent bonding. The discipline blossomed two decades ago with host guest systems. Mingling electronic chemical sensors with supramolecular. As we started our journey with this fascinating family of host molecules two decades ago, we dedicate this chapter to discuss a brief history of the cbn chemistry, structural aspects, physical properties and host. Early on in the history of supramolecular chemistry, people realized that an enzyme and its substrate were a type of hostguest system. Supramolecular hostguest interactions, dynamics and structure. Recent progress in the research on the hostguest chemistry of pillarnarenes. Together, these highly selective, strong yet dynamic. Hostguest chemistry is a branch of supramolecular chemistry in which a host molecule forms a chemical compound with a guest molecule or ion.
Supramolecular chemistry is still a very young field, and so it is difficult to predict its future, but it has already secured a firm position in the chemical sciences. Such a molecular receptor can be incorporated into an electronic chemical sensor so that the anticipated host guest binding event can be transduced directly into electric signals. The discipline blossomed two decades ago with hostguest systems in which i metal ions were complexed to crown ethers and ii small molecules such as urea were bound to larger hosts by means of multiple hydrogen bonds. Supramolecular chemistry and selfassembly special feature. Cryptands, a class of threedimensional macrobicyclic hosts ideally suited for accommodating small guest ions, have played an important role in the early development of supramolecular chemistry. Host guest complexes with altogether five components were prepared as early as 2008 when fujita reported a threecomponent prism that incorporated a heterotriple stack of dad metal porphyrins, following a strategy similar to. Hostguest complexes with altogether five components were prepared as early as 2008 when fujita reported a threecomponent prism that incorporated a heterotriple stack of dad metal porphyrins, following a strategy similar to that depicted in scheme 9. Sir fraser stoddart 2016 nobel laureate in chemistry see news story here.
Supramolecular chemistry of hostguest inclusion complexes. Receptors, coordination and the lock and key analogy. The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small. Host guest supramolecular chemistry of dendritic macromolecules volume. Assuming little in the way of prior knowledge, the book covers the concepts behind the subject, its breadth, applications and the latest contemporary thinking in the area. Dec 11, 2009 since then supramolecular chemistry has matured into a research field in its own right. Supramolecular chemistry is one of the most popular areas of experimental chemistry and it seems set to remain that way for the coming future. New host guest chemistry of supramolecular nanotubes.
Supramolecular hostguest chemistrybased folateriboflavin. For example, biotechnology and nanotechnology are expected to lead to technological revolutions in the near future that will dramatically affect our lifestyles and economies. Because of the highly branched structure and the presence of internal space and binding sites, dendritic macromolecule can serve as host to encapsulate multiple guests, just like a highly branched tree accommodating. No correlation between the guest binding or exchange parameters across different solvents are observed, illustrating the complexity of host and guest solvation in these highlycharged supramolecular systems. Apr 16, 2002 supramolecular chemistry, broadly speaking, entails the study of intermolecular bonding. Supramolecular chemistry is an uptodate, integrated textbook that tells the newcomer to the field everything they need to know to get started. Firstly, through coordinationdriven selfassembly, a rhomboidal metallacycle h with two crown ether units and two chain transfer agent cta units was constructed. Cram established, host guest chemistry, where the host molecule can accommodate another guest molecule. The resulting nano objects have contributed to the new field of nanotechnology. The discipline blossomed two decades ago with host guest systems in which i metal ions were complexed to crown ethers and ii small molecules such as urea were bound to larger hosts by means of multiple hydrogen bonds. One of the new research areas integrating supramolecular chemistry with analytical chemistry is supramolecular analytical chemistry. Hostguest chemistry in supramolecular theranostics.
Thus, with the aid of the postworld war ii advances in synthetic and physical organic chemistry, at. Hostguest supramolecular chemistry of dendritic macromolecules. Since then supramolecular chemistry has matured into a research field in its own right. Host guest chemistry in supramolecular chemistry we usually consider a molecule a host binding another molecule a guest. Traditional chemistry generally focuses on the covalent bonding but supramolecular chemistry monitored by weak interactions of noncovalent bonds. His publications have been cited more than 9222 times with an hindex of 52.
Host guest chemistry is a branch of supramolecular chemistry in which a host molecule forms a chemical compound with a guest molecule or ion. Supramolecular chemistry of anions, wileyvch, new york 1997 j. Supramolecular host guest chemistry allows sensitive and selective recognition of a certain substrate by using a rationally designed receptor. Introduction supramolecular chemistry is o ne of the most popular and rap i d growing areas of. The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the energy. Hostguest chemistry in such twodimensional 2d porous networks is a rapidly expanding field due to potential applications in separation technology, catalysis and nanoscal hostguest chemistry. Classification of supramolecular host guest compounds. Thermodynamic and kinetic selectivity, and discrimination. These complexes are termed supramolecular prodrugs. Methods and limitations in the use of nmr for measuring host guest interactions, in h. From molecules to nanomaterials is a new major reference work which links supramolecular chemistry and nanomaterials. Supramolecular chemistry from molecule to molecular machines vandana bhalla vandana bhalla works as assistant professor at department of chemistry, guru nanak dev university, amritsar, punjab. Jun 12, 2018 supramolecular hostguest complexation of these derivatives with cyclodextrins cds.
The resulting nano objects have contributed to the new field of. Supramolecular chemistry is area of chemistry that studies the relationship and linking molecules into bigger systems. Pdf new host guest chemistry of supramolecular nanotubes. In contrast to related twodimensional crown ethers, cryptands have so far only found limited applications, owing in large part to their relatively. Supramolecular chemistry has developed from early host guest chemistry to selfassembly of small, low molecular building blocks to lager supramolecular aggregates both in solution, in the solid state, and at interfaces.
Host guest modulation employing cyclodextrin as host 2. Hostguest interaction based supramolecular photodynamic. Host guest modulation employing cucurbituril as host 3. Mar 09, 2017 cram established, hostguest chemistry, where the host molecule can accommodate another guest molecule. He has published more than 160 supramolecular chemistry papers. Mingling electronic chemical sensors with supramolecular host. One key division within supramolecular hostguest chemistry in its general sense relates to the stability of a hostguest complex in solution. Conspectushost guest chemistry can greatly improve the selectivity of biomoleculeligand binding on account of recognitiondirected interactions. One key division within supramolecular host guest chemistry in its general sense relates to the stability of a host guest complex in solution. The importance of supramolecular chemistry was established by the research work of nobel laureates donald j. Dear colleagues, neologisms of host guest chemistry by d. In 1978, lehn proposed the term supramolecular chemistry. Eventually, chemists were able to take these concepts and apply.
Based on host guest interactions, supramolecular host molecules may influence the physiochemical and biological properties of guest species, such as solubility, stability, toxicity and therapeutic. Supramolecular chemistry, broadly speaking, entails the study of intermolecular bonding. Herein, we present the construction of a new type of supramolecular hydrogel with tunable strength switched by hostguest interactions via a hierarchical selfassembly strategy. Department of chemistry, emory university, atlanta, ga 30322 supramolecular systemstheir successes, problems, and potentialare discussed with allusion to speci. Binding between host and guest is usually highly specific to the two moieties concerned. Supramolecular hostguest chemistrybased folateriboflavin functionalization and cancer cell labeling of nanoparticles suman pal, chumki dalal, and nikhil r. Robust hostguest chemistry of cucurbitnuril macrocyclic. From molecule to molecular machines indian academy of. Concepts techniques molecular recognition supramolecular reactivity supramolecular aspects of chemical biology self processes supramolecular. Pdf supramolecular chemistry refers to the study of supramolecular assemblies. For the love of physics walter lewin may 16, 2011 duration. Supramolecular chemistry is providing a new approach to developing prodruglike systems, wherein the characteristics of a drug are modified in a beneficial manner by creating host guest complexes that then permit the stimulusinduced release of the active species in a controlled manner. Supramolecular chemistry is the domain of chemistry concerning chemical systems composed of a discrete number of molecules. In addition, functional structures and the actuation of supramolecular assemblies in molecular systems can be controlled efficiently through various host guest chemistry.
633 195 1271 1009 600 1421 1265 38 1342 433 1513 1116 243 332 1452 314 91 373 1248 267 502 1320 1327 50 972 285 1433 334 802 377 1277 149